Guanine nucleotide exchange factor - Wikipedia
WEBGuanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small GTPases act as molecular switches in intracellular signaling pathways and have many downstream targets.
GEFs and GAPs: critical elements in the control of small G proteins
WEBJun 1, 2007 · GEFs and GAPs are multidomain proteins that are regulated by extracellular signals and localized cues that control cellular events in time and space. Recent evidence suggests that these proteins may be potential therapeutic targets for developing drugs to treat various diseases, including cancer.
GEFs and GAPs: Critical Elements in the Control of Small G …
WEBJun 1, 2007 · Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular functions. In general, GEFs turn on signaling by catalyzing the exchange from G-protein-bound GDP to GTP, whereas GAPs terminate signaling by …
GTPase-activating protein - Wikipedia
WEBGTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. [1] GAPs are also known as RGS protein, or RGS proteins, [2] and these proteins are crucial in controlling ...
28.5: Small G proteins, GAPs and GEFs - Biology LibreTexts
WEBApr 17, 2024 · For small G proteins, another mechanism is evoked: the binding of another protein, a GTP Exchange Factor or a GEF, which promotes GTP exchange for the bound GDP. If the Ras:GEF:GDP complex has a 10,000 increase in k off for GTP, the half-life of the bound GDP is 7 seconds.
Regulation of small GTPases by GEFs, GAPs, and GDIs
WEBSmall GTPases use GDP/GTP alternation to actuate a variety of functional switches that are pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate dissociation of the tightly bound GDP, and turned off by GAPs, which accelerate the intrinsically sluggish hydrolysis of GTP. ….
Molecular control of Rab activity by GEFs, GAPs and GDI
WEBFeb 1, 2017 · Their activity can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), they switch between an active GTP-bound state and an inactive GDP-bound state, interacting with downstream effector proteins only in the active state.
Ras activation revisited: role of GEF and GAP systems
WEBThree decades of intense Ras research have disclosed various families of guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) as the two principal regulatory elements of the Ras-GDP/GTP loading status.
Ras superfamily GEFs and GAPs: validated and tractable targets for ...
WEBNov 24, 2010 · Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that control the GDP–GTP cycling of specific members of the Ras superfamily have been shown to contribute to...
Synaptic GAP and GEF Complexes Cluster Proteins Essential for …
WEBJul 13, 2017 · GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at...