Modulation of inflammatory responses by gastrointestinal Prevotella …
WEBFeb 1, 2021 · Using gnotobiotic mice and an experimental colitis mouse model, we showed that Prevotella spp. can causally exacerbate intestinal inflammation. Detailed microbial community profiling combined with metabolome analysis revealed a striking ability of Prevotella spp. to perturb the gut microbiome and to …
The immune response to Prevotella bacteria in chronic inflammatory …
WEBJun 20, 2017 · Studies in mice support a causal role of Prevotella as colonization experiments promote clinical and inflammatory features of human disease. When compared with strict commensal bacteria, Prevotella exhibit increased inflammatory properties, as demonstrated by augmented release of inflammatory mediators from immune cells and various stromal cells.
Perturbation of the gut microbiome by Prevotella spp. enhances …
WEBMay 20, 2020 · Here we demonstrate that colonization of mice with a member of the genus Prevotella, which has been previously associated to colitis in mice, exacerbates intestinal inflammation.
Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella …
WEBThis study was undertaken to test the ability of a human gut-derived commensal to modulate immune response and treat arthritis in a humanized mouse model. Methods: We isolated a commensal bacterium, Prevotella histicola, that is native to the human gut and has systemic immune effects when administered enterally.
P090 Prevotella copri promotes colitis in mice by reducing …
WEBJan 24, 2024 · Prevotella copri is a common human gut microbe that has been linked to inflammatory disorders. Methods C57BL/6 mice were divided into four groups: normal control group, P. copri group, DSS model group, DSS model+ P. copri group.
Perturbation of the gut microbiome by Prevotella spp. enhances …
WEBMay 20, 2020 · We found that P. intestinalis colonization of WT specific pathogen-free (SPF) mice, devoid of any Prevotella spp. in the intestine, reshapes the resident intestinal microbial community and significantly alters the metabolic profile in the intestine.
Clinical translation of anti-inflammatory effects of Prevotella ...
WEBMay 4, 2023 · Here we describe the translational development of EDP1815, a single strain of Prevotella histicola, and demonstrate that it can modify systemic inflammation in humans across Th1, Th2 and Th17 driven inflammation through its action in the gut.
Prevotella diversity, niches and interactions with the human host - Nature
WEBMay 28, 2021 · Prevotella is a diverse genus of Gram-negative anaerobic bacteria that was first described in 1990 by Shar and Collins to include some oral species with specific phenotypic traits (moderately...
Oral Prevotella Species and Their Connection to Events of Clinical ...
WEBJan 6, 2022 · A recent study using a mouse model (Wu et al., 2021) demonstrated that the episodic aspiration of oral commensals, such as P. melaninogenica, Veillonella parvula, and S. mitis, leads to dysbiosis and low-dose inflammation in the lower airways; the consequence is a reduced susceptibility to pathogenic Streptococcus pneumoniae via …
Expansion of intestinal Prevotella copri correlates with enhanced ...
WEBNov 5, 2013 · Colonization of mice with P. copri enhanced susceptibility to chemical colitis, consistent with a pro-inflammatory potential of this organism. Taken together, our results suggest that NORA-associated P. copri may contribute to …