Animal models of ischemic stroke and their application in …
WEBJul 2, 2015 · This review outlines the most frequently used rodent stroke models and discusses their strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is not feasible because ischemic stroke in humans is a heterogeneous disorder with a complex pathophysiology.
Animal models of stroke - Li - 2021 - Wiley Online Library
WEBSep 15, 2021 · Tools. Abstract. Stroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens.
Behavioral tests in rodent models of stroke - PMC - National …
WEBIn this review, we summarize commonly used motor/sensorimotor and cognition tests in rodent models of stroke. Specifically, we first briefly introduce the objective and procedure of each behavioral test. Next, we summarize the application of each test in both ischemic stroke and hemorrhagic stroke.
Blood substitution therapy rescues the brain of mice from ... - Nature
WEBAug 25, 2020 · Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.
A Method for Generate a Mouse Model of Stroke: Evaluation of Parameters ...
WEBMar 27, 2014 · Experimental stroke models using genetically modified mice could aid in unraveling the complex pathophysiology triggered by ischemic brain injury.
Deficits in motor and cognitive functions in an adult mouse
WEBNov 26, 2020 · Ischemic stroke is mainly caused by atherothrombosis of large cervical and intracranial arteries or by embolism from the heart. It is the most common type of stroke, contributing to 78–85% of...
High-resolution micro-CT for 3D infarct characterization and ...
WEBOct 19, 2022 · Ischemic stroke is the leading cause of mortality and disability and the second leading cause of dementia in western countries 1. The only treatment available focuses on reperfusion of the...
Validity and Reliability of Neurological Scores in Mice Exposed to ...
WEBAug 15, 2019 · Despite their simplicity, the Bederson (0–5) score, modified neurological severity score, and subjective overall impression have reasonable validity and reliability in the acute stroke phase. The Bederson (0–5) score equally distinguishes infarct volume in small and large infarcts.
Comparison of Large Animal Models for Acute Ischemic Stroke: …
WEBFeb 15, 2022 · In this article, we review key characteristics of the main large animal models used in translational studies of acute ischemic stroke, regarding (1) anatomy and physiology of the cerebral vasculature, including brain morphology, coagulation characteristics, and immune function; (2) ischemic stroke modeling, including vessel occlusion approaches ...
Prediction of Stroke Outcome in Mice Based on Noninvasive MRI …
WEBSep 25, 2023 · Summary: Systematic analysis of stroke outcome predictors in mice is lacking. We developed a tool to predict late pellet reaching performance based on early stroke localization in a diverse cohort of 215 mice. Graphical Abstract.