Syngeneic Mouse Models | Charles River - Charles River …
WEBCharles River offers a broad range of syngeneic mouse models with well-characterized responses to known immune checkpoint inhibitors (e.g., anti-PDL-1, anti-PD-1, anti-CTLA-4), immune profiling, and genetic evaluation (e.g., whole exome sequencing, RNA-seq).
Syngeneic Tumor Mouse Models: The Pros and Cons - Crown Bio
WEBJul 8, 2024 · Syngeneic models are allografts immortalized from mouse cancer cell lines, which are then engrafted back into the same inbred immunocompetent mouse strain. The identical host and cell line strain means that tumor rejection doesn’t occur, creating an immunocompetent model for immunotherapy assessment.
Syngeneic Studies - The Jackson Laboratory
WEBA syngeneic mouse model, also known as an allograft mouse tumor system, provides an effective approach for studying how cancer therapies perform in the presence of a functional immune system.
Mouse Tumor Models for Advanced Cancer Immunotherapy
WEBJun 9, 2020 · This review discusses the current immunocompetent and immunocompromised mouse models of human tumors that are used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.
TISMO: syngeneic mouse tumor database to model tumor …
WEBJan 7, 2022 · Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical mouse strains. They are widely used tools for studying tumor immunity and immunotherapy response in the context of a fully functional murine immune system.
Immune phenotyping of diverse syngeneic murine brain tumors
WEBAug 6, 2020 · Here, we generate distinct imageable syngeneic mouse GBM-tumor models and utilize RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
Machine learning on syngeneic mouse tumor profiles to model …
WEBOct 14, 2022 · Syngeneic mouse models are cancer cells implanted into immunocompetent host mice of the same genetic background (12, 13) and faithfully recapitulate the complexity of cancer cells and their …
Leukemia’s Next Top Model? Syngeneic Models to Advance …
WEBMar 25, 2022 · Syngeneic mouse models utilize murine tumor models and implant them into immunocompetent mice. This provides an alternative model, reducing the need for complicated breeding strategies while maintaining a matched immune system, stromal compartment, and leukemia burden.
Different syngeneic tumors show distinctive intrinsic tumor …
WEBFeb 28, 2022 · We modeled loss of function (LOF) in four common anti-PD-1 antibody-responsive syngeneic tumors, MC38, Hepa1-6, CT-26 and EMT-6, by systematical depleting a series of TIL lineages to explore the...
Tumor-immune profiling of murine syngeneic tumor models as a …
WEBNov 2, 2018 · In this report, we present a detailed characterization of four commonly used mouse syngeneic tumor models. This endeavor is largely descriptive and is focused primarily on understanding model differences within the tumor-immune microenvironment and framing these features to clinically relevant tumor-immune categories.